Caspase 3 Subunit p17 Cleaved-Asp175 (CASP3 p17 Cleaved-D175) Antibody

Caspase 3 (p17,Cleaved-Asp175) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.

Target	Caspase 3 Subunit p17 Cleaved-Asp175 (CASP3 p17 Cleaved-D175)
Clonality	Polyclonal
Target Modification	Asp175
Modification	Cleaved
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Form	Liquid
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42574 (UniProt, ExPASy)
UniProt Secondary AC	A8K5M2, D3DP53, Q96AN1, Q96KP2
UniProt Entry Name	CASP3_HUMAN
Gene Symbol	CASP3
KEGG	hsa:836
Ensembl	ENSG00000164305
String	9606.ENSP00000311032
Molecular Weight	17 kDa
Buffer	PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Specificity	Caspase 3 (p17,Cleaved-Asp175) Antibody detects endogenous levels of fragment of activated Caspase 3 resulting from cleavage adjacent to Asp175.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Caspase 3 Subunit p17 Cleaved-Asp175 (CASP3 p17 Cleaved-D175)

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