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Circadian Locomotor Output Cycles Protein Kaput (CLOCK) Cell ELISA Kit
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Catalogue No: abx595660
Price:
US$572.75
(Size: 96 tests)
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Clock Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Research Articles on CLOCK
| Introduction | Circadian Locomotor Output Cycles Protein Kaput (CLOCK) is a transcription factor involved in circadian rhythm. Based off studies on mice and fruit flies, CLOCK can dimerise with BMAL1 and bind to E-box elements in DNA to increase mRNA for PER proteins, thereby increasing those proteins’ expression. Mutations in CLOCK are associated with increased circadian cycles, sympathetic behaviour, insomnia, depression, and metabolic disorders. |
| Target | CLOCK |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Validity | 6 months. |
| UniProt Primary AC | O15516 (UniProt, ExPASy) |
| UniProt Secondary AC | A0AV01, A2I2N9, O14516, Q9UIT8 |
| UniProt Entry Name | CLOCK_HUMAN |
| Gene Symbol | CLOCK |
| GeneID | 9575 |
| OMIM | 601851 |
| HGNC | 2082 |
| KEGG | hsa:9575 |
| Ensembl | ENSG00000134852 |
| String | 9606.ENSP00000308741 |
| Detection Method | Colorimetric |
| Plate Coating | Uncoated |
| Substrate | TMB |
| Detection Antibody Conjugation | HRP |
| Availability | Shipped within 1-2 weeks. |
| Note | This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |