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Polyribonucleotide 5'-Hydroxyl-Kinase Clp1 (CLP1) Antibody
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Catalogue No: abx029312
Price:
US$290.00
(Size: 80 µl)
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Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
Research Articles on Polyribonucleotide 5'-Hydroxyl-Kinase Clp1 (CLP1)
| Target | Polyribonucleotide 5'-Hydroxyl-Kinase Clp1 (CLP1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 308-336 amino acids from the C-terminal region of human CLP1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92989 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R7J6, B4DTI8 |
| UniProt Entry Name | CLP1_HUMAN |
| KEGG | hsa:10978 |
| String | 9606.ENSP00000434995 |
| Molecular Weight | Calculated MW: 47.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow, Chicken and Monkey CLP1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |