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Calsyntenin 1 (CLSTN1) Antibody
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Catalogue No: abx030664
Price:
US$326.25
(Size: 80 µl)
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Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
Research Articles on Calsyntenin 1 (CLSTN1)
| Target | Calsyntenin 1 (CLSTN1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 15-42 amino acids from the N-terminal region of human CLSTN1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O94985 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K183, Q5SR52, Q5UE58, Q71MN0, Q8N4K9 |
| UniProt Entry Name | CSTN1_HUMAN |
| Gene Symbol | CLSTN1 |
| KEGG | hsa:22883 |
| String | 9606.ENSP00000366513 |
| Molecular Weight | Calculated MW: 110 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat CLSTN1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |