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Cluster Of Differentiation 14 (CD14) Antibody
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Catalogue No: abx239987
Price:
US$406.00
(Size: 100 µg)
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Cluster Of Differentiation 14 (CD14) Antibody is a Rabbit Polyclonal antibody for the detection of CD14. Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Research Articles on Cluster Of Differentiation 14 (CD14)
| Target | Cluster Of Differentiation 14 (CD14) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | CD14 molecule |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P08571 (UniProt, ExPASy) |
| UniProt Secondary AC | Q53XT5, Q96FR6, Q96L99, Q9UNS3 |
| UniProt Entry Name | CD14_HUMAN |
| Gene Symbol | CD14 |
| GeneID | 929 |
| OMIM | 158120 |
| HGNC | 1628 |
| KEGG | hsa:929 |
| Ensembl | ENSG00000170458 |
| String | 9606.ENSP00000304236 |
| Molecular Weight | Observed MW: 50-55 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |