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Collagen Type I Alpha 2 (COL1A2) Antibody
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Catalogue No: abx239920
Price:
US$406.00
(Size: 100 µg)
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Collagen Type I Alpha 2 (COL1A2) Antibody is a Mouse Monoclonal antibody for the detection of Collagen Type I Alpha 2. This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A2A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Research Articles on Collagen Type I Alpha 2 (COL1A2)
| Target | Collagen Type I Alpha 2 (COL1A2) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | IHC: 1/2000 - 1/8000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | collagen, type I, alpha 2 |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P08123 (UniProt, ExPASy) |
| UniProt Entry Name | CO1A2_HUMAN |
| Gene Symbol | COL1A2 |
| GeneID | 1278 |
| OMIM | 120160 |
| HGNC | 2198 |
| KEGG | hsa:1278 |
| Ensembl | ENSG00000164692 |
| String | 9606.ENSP00000297268 |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |