Collagen Type I Alpha 2 (COL1A2) Antibody

Collagen Type I Alpha 2 (COL1A2) Antibody is a Mouse Monoclonal antibody for the detection of Collagen Type I Alpha 2.

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A2A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Target	Collagen Type I Alpha 2 (COL1A2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	IHC: 1/2000 - 1/8000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	collagen, type I, alpha 2
Isotype	IgG1
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by Protein A and Protein G affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P08123 (UniProt, ExPASy)
UniProt Entry Name	CO1A2_HUMAN
Gene Symbol	COL1A2
GeneID	1278
OMIM	120160
HGNC	2198
KEGG	hsa:1278
Ensembl	ENSG00000164692
String	9606.ENSP00000297268
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Collagen Type I Alpha 2 (COL1A2)

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