Cartilage Oligomeric Matrix Protein (COMP) Antibody

COMP Antibody is a Rabbit Polyclonal antibody against COMP. The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Target	Cartilage Oligomeric Matrix Protein (COMP)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human COMP.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49747 (UniProt, ExPASy)
UniProt Secondary AC	B4DKJ3, O14592, Q16388, Q16389, Q2NL86, Q8N4T2
UniProt Entry Name	COMP_HUMAN
Gene Symbol	COMP
GeneID	1311
NCBI Accession	NP_000086.2
KEGG	hsa:1311
String	9606.ENSP00000222271
Molecular Weight	Calculated MW: 83 kDa Observed MW: 110 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cartilage Oligomeric Matrix Protein (COMP)

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