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Catechol O-Methyltransferase (COMT) Antibody
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Catalogue No: abx004737
Price:
US$203.00
(Size: 20 µl)
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COMT Antibody is a Rabbit Polyclonal antibody against COMT. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Research Articles on Catechol O-Methyltransferase (COMT)
| Target | Catechol O-Methyltransferase (COMT) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P21964 (UniProt, ExPASy) |
| UniProt Secondary AC | A8MPV9, Q6IB07, Q6ICE6, Q9BWC7 |
| UniProt Entry Name | COMT_HUMAN |
| Gene Symbol | COMT |
| GeneID | 1312 |
| NCBI Accession | NP_009294.1 |
| KEGG | hsa:1312 |
| String | 9606.ENSP00000354511 |
| Molecular Weight | Calculated MW: 30 kDa Observed MW: 28-32 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1.53 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |