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Gap Junction Alpha-8 Protein / CX50 (GJA8) Antibody
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Catalogue No: abx028505
Price:
US$326.25
(Size: 80 µl)
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GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.
Research Articles on Gap Junction Alpha-8 Protein / CX50 (GJA8)
| Target | Gap Junction Alpha-8 Protein / CX50 (GJA8) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 99-130 amino acids from the N-terminal region of human Connexin 50. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P48165 (UniProt, ExPASy) |
| UniProt Secondary AC | A7L5M5, Q5VVN9, Q9NP25 |
| UniProt Entry Name | CXA8_HUMAN |
| NCBI Accession | NP_005258.2 |
| KEGG | hsa:2703 |
| String | 9606.ENSP00000358238 |
| Molecular Weight | Calculated MW: 48.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |