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COP9 Signalosome Subunit 7A (COPS7A) Antibody
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Catalogue No: abx027027
Price:
US$326.25
(Size: 80 µl)
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Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Research Articles on COP9 Signalosome Subunit 7A (COPS7A)
| Target | COP9 Signalosome Subunit 7A (COPS7A) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UBW8 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K9A6, Q9NVX3, Q9UJW4 |
| UniProt Entry Name | CSN7A_HUMAN |
| Gene Symbol | COPS7A |
| String | 9606.ENSP00000438115 |
| Molecular Weight | Calculated MW: 30.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse COPS7A. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |