COX11, Cytochrome C Oxidase Copper Chaperone (COX10) Antibody
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Price:
US$290.00
(Size: 80 µl)
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Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
Target |
COX11, Cytochrome C Oxidase Copper Chaperone (COX10) |
Clonality |
Polyclonal |
Reactivity |
Human |
Tested Applications |
ELISA, WB, IHC, FCM |
Host |
Rabbit |
Recommended dilutions |
WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
KLH-conjugated synthetic peptide between 383-410 amino acids from the C-terminal region of human COX10. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Purified through a protein A column, followed by peptide affinity purification. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q12887 (UniProt,
ExPASy)
|
UniProt Secondary AC |
B2R6U5, B4DJ50, O15334, Q969F7 |
UniProt Entry Name |
COX10_HUMAN |
KEGG |
hsa:1352
|
String |
9606.ENSP00000261643
|
Molecular Weight |
Calculated MW: 48.9 kDa |
Buffer |
PBS containing 0.09% sodium azide. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on COX11, Cytochrome C Oxidase Copper Chaperone (COX10)