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Phospholipase A2, Cytosolic (cPLA2) Antibody
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Catalogue No: abx000706
Price:
US$203.00
(Size: 20 µl)
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cPLA2 Antibody is a Rabbit Polyclonal antibody against cPLA2. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Research Articles on Phospholipase A2, Cytosolic (cPLA2)
| Target | Phospholipase A2, Cytosolic (cPLA2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 550-749 of human PLA2G4A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P47712 (UniProt, ExPASy) |
| UniProt Secondary AC | B1AKG4, Q29R80 |
| UniProt Entry Name | PA24A_HUMAN |
| Gene Symbol | PLA2G4A |
| GeneID | 5321 |
| NCBI Accession | NP_077734.1 |
| KEGG | hsa:5321 |
| String | 9606.ENSP00000356436 |
| Molecular Weight | Calculated MW: 85 kDa Observed MW: 115 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |