Cleavage And Polyadenylation Specificity Factor Subunit 4 (CPSF4) Antibody

Inhibition of the nuclear export of poly (A) containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.

Target	Cleavage And Polyadenylation Specificity Factor Subunit 4 (CPSF4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 96-123 amino acids from the Central region of human CPSF4.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O95639 (UniProt, ExPASy)
UniProt Secondary AC	D6W5S8, Q6FGE6, Q86TF8, Q9BTW6
UniProt Entry Name	CPSF4_HUMAN
Gene Symbol	CPSF4
KEGG	hsa:10898
String	9606.ENSP00000292476
Molecular Weight	Calculated MW: 30.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat, Cow and Xenopus CPSF4.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cleavage And Polyadenylation Specificity Factor Subunit 4 (CPSF4)

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