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Carnitine O-Palmitoyltransferase 1, Brain Isoform (CPT1C) Antibody
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Catalogue No: abx026275
Price:
US$326.25
(Size: 80 µl)
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The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.
Research Articles on Carnitine O-Palmitoyltransferase 1, Brain Isoform (CPT1C)
| Target | Carnitine O-Palmitoyltransferase 1, Brain Isoform (CPT1C) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 752-782 amino acids from the C-terminal region of human CPT1C. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8TCG5 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K0Z8, Q5K6N5, Q8N6Q9, Q8NDS6, Q8TE84 |
| UniProt Entry Name | CPT1C_HUMAN |
| Gene Symbol | CPT1C |
| KEGG | hsa:126129 |
| String | 9606.ENSP00000376303 |
| Molecular Weight | Calculated MW: 91 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |