Creatine Kinase B Antibody

Creatine Kinase (CK) is a dimeric enzyme composed of either M or B-type subunits. The resulting isoenzymes are expressed at varying levels in different tissues. CK-BB, a cytoplasmic predominantly found in brain tissues, participates in energy homeostasis, reversibly catalyzing the transfer of a phosphate group between ATP and target proteins such as a creatine phosphate. CK-BB exists in normally neglible amounts in the serum of adults, overexpression of CK-BB is associated with cancers of the breast, ovary, prostate, colon, and in small-cell lung cancer. Global assessment of changes in serum levels of CK-BB, CK-MB and CK-MM, are used as a marker for myocardial infarction.

Target	Creatine Kinase B
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 240-270 amino acids from the C-terminal region of human Creatine Kinase B.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P12277 (UniProt, ExPASy)
UniProt Secondary AC	A8K236, B2R5R4, Q2LE07, Q6FG40, Q9UC66
UniProt Entry Name	KCRB_HUMAN
NCBI Accession	NP_001814.2
KEGG	hsa:1152
String	9606.ENSP00000299198
Molecular Weight	Calculated MW: 42.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Creatine Kinase B

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