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Adapter Molecule Crk (CRK) Antibody
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Catalogue No: abx011986
Price:
US$420.50
(Size: 100 µl)
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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Research Articles on Adapter Molecule Crk (CRK)
| Target | Adapter Molecule Crk (CRK) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, IF/ICC, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human CRK expressed in E. coli. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P46108 (UniProt, ExPASy) |
| UniProt Secondary AC | A8MWE8, B0LPE8, D3DTH6, Q96GA9, Q96HJ0 |
| UniProt Entry Name | CRK_HUMAN |
| Gene Symbol | CRK |
| GeneID | 1398 |
| OMIM | 164762 |
| HGNC | 2362 |
| KEGG | hsa:1398 |
| Ensembl | ENSG00000167193 |
| String | 9606.ENSP00000300574 |
| Molecular Weight | 42 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |