CREB-Regulated Transcription Coactivator 2 (CRTC2) Antibody

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Catalogue No: abx011916
Price: US$478.50
(Size: 100 µl)
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Western blot analysis using CRTC2 antibody against Hela (1) and HEK293 (2) cell lysate.
CREB-Regulated Transcription Coactivator 2 (CRTC2) Antibody CREB-Regulated Transcription Coactivator 2 (CRTC2) Antibody CREB-Regulated Transcription Coactivator 2 (CRTC2) Antibody

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Datasheet SDS
the transducer of regulated CREB protein 2 (TORC2) is a cAMP responsive coactivator that, in concert with LKB1 and AMPK, controls glucose homeostasis in the liver. Under fasting conditions, cytoplasmic TORC2 is transported to the nucleus where it binds to CREB and stimulates gluconeogenisis. Re-feeding and the ensuing insulin response inhibits gluconeogenic gene expression by promoting the phosphorylation, cytoplasmic export and degradation of TORC2. TORC2 is phosphorylated by the kinase QIK which in turn is activated by phosphorylation at Ser358 by insulin-activated Akt2. Phosphorylated TORC2 is subsequently ubiquitinylated at Lys 628 and degraded by the 26S proteasome. TORC2 protein levels and activity are increased in diabetes owing to a block in TORC2 phosphorylation, implicating this pathway in the pathogenesis of diabetes. The CREB/TORC2 regulatory axis controls the normal pattern of germinal center (GC) B cell gene activation/repression that promotes B cell development and circumvents GC lymphomagenesis.

Target CREB-Regulated Transcription Coactivator 2 (CRTC2)
Clonality Monoclonal
Reactivity Human, Monkey
Tested Applications ELISA, WB, IHC, IF/ICC, FCM
Host Mouse
Recommended dilutions ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human CRTC2 expressed in E. coli.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q53ET0 (UniProt, ExPASy)
UniProt Secondary AC Q6UUV8, Q7Z3X7, Q8N332
GeneID 200186
KEGG hsa:200186
Molecular Weight 80 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on CREB-Regulated Transcription Coactivator 2 (CRTC2)
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