Cystatin-B (CSTB) Antibody

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).

Target	Cystatin-B (CSTB)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 10-39 amino acids from the Central region of human CSTB.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04080 (UniProt, ExPASy)
UniProt Entry Name	CYTB_HUMAN
KEGG	hsa:1476
String	9606.ENSP00000291568
Molecular Weight	Calculated MW: 11.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow and Sheep CSTB.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cystatin-B (CSTB)

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