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Cystatin-B (CSTB) Antibody
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Catalogue No: abx002766
Price:
US$203.00
(Size: 20 µl)
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CSTB Antibody is a Rabbit Polyclonal antibody against CSTB. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Research Articles on Cystatin-B (CSTB)
| Target | Cystatin-B (CSTB) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-98 of human CSTB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P04080 (UniProt, ExPASy) |
| UniProt Entry Name | CYTB_HUMAN |
| Gene Symbol | CSTB |
| GeneID | 1476 |
| NCBI Accession | NP_000091.1 |
| KEGG | hsa:1476 |
| String | 9606.ENSP00000291568 |
| Molecular Weight | Calculated MW: 11 kDa Observed MW: 14/11 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |