Catenin Beta 1 (CTNNB1) Antibody

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Target	Catenin Beta 1 (CTNNB1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/50, IF/ICC: 1/50, FCM: 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human CTNNB1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35222 (UniProt, ExPASy)
UniProt Secondary AC	A8K1L7, Q8NEW9, Q8NI94, Q9H391
Gene Symbol	CTNNB1
Molecular Weight	Calculated MW: 85.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Zebrafish CTNNB1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Catenin Beta 1 (CTNNB1)

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