Cortactin (CTTN) Antibody

CTTN Antibody is a Rabbit Polyclonal antibody against CTTN. This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: regulating the interactions between components of adherens-type junctions and organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Target	Cortactin (CTTN)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 301-400 of human Cortactin.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14247 (UniProt, ExPASy)
UniProt Secondary AC	Q8N707, Q96H99
UniProt Entry Name	SRC8_HUMAN
Gene Symbol	CTTN
GeneID	2017
NCBI Accession	NP_005222.2
KEGG	hsa:2017
Molecular Weight	Calculated MW: 62 kDa Observed MW: 80 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cortactin (CTTN)

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