G1/S-Specific Cyclin-D1 (CCND1) Antibody

G1/S-Specific Cyclin-D1 (CCND1) Antibody is a Rabbit Polyclonal antibody for the detection of Cyclin D1.

CCND1 (cyclin D1),also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family,whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle.CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6,whose activity is required for cell cycle G1/S transition.The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma (MCL) due to the chromosomal translocation.CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

Target	G1/S-Specific Cyclin-D1 (CCND1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	cyclin D1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P24385 (UniProt, ExPASy)
UniProt Secondary AC	Q6LEF0
UniProt Entry Name	CCND1_HUMAN
Gene Symbol	CCND1
GeneID	595
OMIM	168461
HGNC	1582
KEGG	hsa:595
Ensembl	ENSG00000110092
String	9606.ENSP00000227507
Molecular Weight	Observed MW: 36 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on G1/S-Specific Cyclin-D1 (CCND1)

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