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Steroid 17-Alpha-Hydroxylase/17,20 Lyase (CYP17A1) Antibody
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Catalogue No: abx033739
Price:
US$326.25
(Size: 80 µl)
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CYP17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17, 20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in CYP17A1 gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Research Articles on Steroid 17-Alpha-Hydroxylase/17,20 Lyase (CYP17A1)
| Target | Steroid 17-Alpha-Hydroxylase/17,20 Lyase (CYP17A1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 358-388 amino acids from the Central region of human CYP17A1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P05093 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5TZV7 |
| UniProt Entry Name | CP17A_HUMAN |
| NCBI Accession | NP_000093.1 |
| KEGG | hsa:1586 |
| String | 9606.ENSP00000358903 |
| Molecular Weight | Calculated MW: 57.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Monkey CYP17A1. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |