Cytochrome P450 27B1 (CYP27B1) Antibody

CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha, 25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Target	Cytochrome P450 27B1 (CYP27B1)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/10 - 1/50, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human CYP27B1.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O15528 (UniProt, ExPASy)
UniProt Secondary AC	B2RC61, Q548T3
UniProt Entry Name	CP27B_HUMAN
Gene Symbol	CYP27B1
GeneID	1594
OMIM	264700
NCBI Accession	NP_000776.1
HGNC	2606
KEGG	hsa:1594
Ensembl	ENSG00000111012
String	9606.ENSP00000228606
Molecular Weight	Calculated MW: 56.5 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cytochrome P450 27B1 (CYP27B1)

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