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Cytochrome P450 2C19 (CYP2C19) Antibody
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Catalogue No: abx032948
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
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CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes.
Research Articles on Cytochrome P450 2C19 (CYP2C19)
| Target | Cytochrome P450 2C19 (CYP2C19) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 257-285 amino acids from the Central region of human CYP2C19. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P33261 (UniProt, ExPASy) |
| UniProt Secondary AC | P33259, Q8WZB1, Q8WZB2, Q9UCD4 |
| UniProt Entry Name | CP2CJ_HUMAN |
| KEGG | hsa:1557 |
| String | 9606.ENSP00000360372 |
| Molecular Weight | Calculated MW: 55.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |