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Cytochrome P450 2D6 (CYP2D6) Antibody
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Catalogue No: abx028111
Price:
US$326.25
(Size: 80 µl)
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on Cytochrome P450 2D6 (CYP2D6)
| Target | Cytochrome P450 2D6 (CYP2D6) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P10635 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16752, Q2XND6, Q2XND7, Q2XNE0, Q6B012, Q6NXU8 |
| UniProt Entry Name | CP2D6_HUMAN |
| Gene Symbol | CYP2D6 |
| GeneID | 1565 |
| OMIM | 124030 |
| HGNC | 2625 |
| KEGG | hsa:1565 |
| Ensembl | ENSG00000100197 |
| String | 9606.ENSP00000353820 |
| Molecular Weight | Calculated MW: 55.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat CYP2D6. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |