Cytochrome P450 2D6 (CYP2D6) Antibody

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Cytochrome P450 2D6 (CYP2D6)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10635 (UniProt, ExPASy)
UniProt Secondary AC	Q16752, Q2XND6, Q2XND7, Q2XNE0, Q6B012, Q6NXU8
UniProt Entry Name	CP2D6_HUMAN
Gene Symbol	CYP2D6
GeneID	1565
OMIM	124030
HGNC	2625
KEGG	hsa:1565
Ensembl	ENSG00000100197
String	9606.ENSP00000353820
Molecular Weight	Calculated MW: 55.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat CYP2D6.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cytochrome P450 2D6 (CYP2D6)

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