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Cytochrome P450 2E1 (CYP2E1) Antibody
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Catalogue No: abx034041
Price:
US$326.25
(Size: 80 µl)
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CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Research Articles on Cytochrome P450 2E1 (CYP2E1)
| Target | Cytochrome P450 2E1 (CYP2E1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 402-429 amino acids from the C-terminal region of human CYP2E1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P05181 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5VZD5, Q6NWT9, Q9UK47 |
| UniProt Entry Name | CP2E1_HUMAN |
| Gene Symbol | CYP2E1 |
| GeneID | 1571 |
| OMIM | 124040 |
| HGNC | 2631 |
| KEGG | hsa:1571 |
| Ensembl | ENSG00000130649 |
| String | 9606.ENSP00000440689 |
| Molecular Weight | Calculated MW: 56.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |