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Cytochrome P450 3A4 (CYP3A4) Antibody
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Catalogue No: abx025438
Price:
US$326.25
(Size: 80 µl)
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This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product. This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.
Research Articles on Cytochrome P450 3A4 (CYP3A4)
| Target | Cytochrome P450 3A4 (CYP3A4) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/100 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 228-255 amino acids from human CYP3A4. |
| Isotype | IgM |
| Form | Liquid |
| Purification | Purified Mouse Monoclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P08684 (UniProt, ExPASy) |
| UniProt Secondary AC | P05184, Q16757, Q9UK50 |
| UniProt Entry Name | CP3A4_HUMAN |
| Gene Symbol | CYP3A4 |
| GeneID | 1576 |
| OMIM | 124010 |
| HGNC | 2637 |
| KEGG | hsa:1576 |
| Ensembl | ENSG00000160868 |
| String | 9606.ENSP00000337915 |
| Molecular Weight | Calculated MW: 57.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Please enquire. |
| Note | This product is for research use only. |