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Cytokeratin 5 (CK-5) Antibody
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Catalogue No: abx015735
Price:
US$420.50
(Size: 100 µl)
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Cytokeratin 5, also known as CK5, KRT5.It is a member of the keratin gene family.Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides).The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues.This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14.The type II cytokeratins are clustered in a region of chromosome 12q12-q13.At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.Cytokeratin 5 is expressed in normal basal cells.Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB).Defects in KRT5 are a cause of epidermolysis bullosa simplex.
Research Articles on Cytokeratin 5 (CK-5)
| Target | Cytokeratin 5 (CK-5) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of Cytokeratin 5 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P13647 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6PI71, Q6UBJ0, Q8TA91 |
| UniProt Entry Name | K2C5_HUMAN |
| Gene Symbol | KRT5 |
| GeneID | 3852 |
| OMIM | 131760 |
| HGNC | 6442 |
| KEGG | hsa:3852 |
| Ensembl | ENSG00000186081 |
| String | 9606.ENSP00000252242 |
| Molecular Weight | 62.3 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |