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Cytokeratin (Pan) (CK-5) Antibody
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Catalogue No: abx015732
Price:
US$420.50
(Size: 100 µl)
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Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides).The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues.Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue.Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells.Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors.
Research Articles on Cytokeratin (Pan) (CK-5)
| Target | Cytokeratin (Pan) (CK-5) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC, IF/ICC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of CK5 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P13647 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6PI71, Q6UBJ0, Q8TA91 |
| UniProt Entry Name | K2C5_HUMAN |
| Gene Symbol | KRT5 |
| GeneID | 3852 |
| OMIM | 131760 |
| HGNC | 6442 |
| KEGG | hsa:3852 |
| Ensembl | ENSG00000186081 |
| String | 9606.ENSP00000252242 |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |