Disheveled-Associated Activator of Morphogenesis 1 (DAAM1) Antibody

Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton. Recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein.

Target	Disheveled-Associated Activator of Morphogenesis 1 (DAAM1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human DAAM1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9Y4D1 (UniProt, ExPASy)
UniProt Secondary AC	Q86U34, Q8N1Z8, Q8TB39
UniProt Entry Name	DAAM1_HUMAN
Gene Symbol	DAAM1
String	9606.ENSP00000378557
Molecular Weight	Calculated MW: 123 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse DAAM1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Disheveled-Associated Activator of Morphogenesis 1 (DAAM1)

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