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Deoxycytidine Kinase (DCK) Antibody
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Catalogue No: abx033167
Price:
US$290.00
(Size: 80 µl)
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Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.
Research Articles on Deoxycytidine Kinase (DCK)
| Target | Deoxycytidine Kinase (DCK) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, IP: 1/500 - 1/1000. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 171-200 amino acids from the C-terminal region of human DCK. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P27707 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R8V6, Q5TZY7, Q6FI11 |
| UniProt Entry Name | DCK_HUMAN |
| NCBI Accession | NP_000779.1 |
| KEGG | hsa:1633 |
| String | 9606.ENSP00000286648 |
| Molecular Weight | Calculated MW: 30.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |