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DNA Damage-Binding Protein 2 (DDB2) Antibody
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Catalogue No: abx001528
Price:
US$203.00
(Size: 20 µl)
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DDB2 Antibody is a Rabbit Polyclonal antibody against DDB2. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
Research Articles on DNA Damage-Binding Protein 2 (DDB2)
| Target | DNA Damage-Binding Protein 2 (DDB2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-315 of human DDB2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92466 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R875, Q76E54, Q76E55, Q76E56, Q76E57 |
| UniProt Entry Name | DDB2_HUMAN |
| Gene Symbol | DDB2 |
| GeneID | 1643 |
| NCBI Accession | NP_000098.1 |
| KEGG | hsa:1643 |
| String | 9606.ENSP00000256996 |
| Molecular Weight | Calculated MW: 48 kDa Observed MW: 48 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |