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DNA Damage Inducible Transcript 3 (DDIT3) Antibody
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Catalogue No: abx000607
Price:
US$203.00
(Size: 20 µl)
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DDIT3 Antibody is a Rabbit Polyclonal antibody against DDIT3. This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
Research Articles on DNA Damage Inducible Transcript 3 (DDIT3)
| Target | DNA Damage Inducible Transcript 3 (DDIT3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/5000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-169 of human DDIT3/CHOP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P35638 (UniProt, ExPASy) |
| UniProt Secondary AC | F8VS99 |
| UniProt Entry Name | DDIT3_HUMAN |
| Gene Symbol | DDIT3 |
| GeneID | 1649 |
| NCBI Accession | NP_004074.2 |
| KEGG | hsa:1649 |
| String | 9606.ENSP00000448665 |
| Molecular Weight | Calculated MW: 19 kDa Observed MW: 27 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |