Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Three isoforms of this gene are generated by alternative splicing. [PROW].
Target |
Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) |
Clonality |
Monoclonal |
Reactivity |
Human |
Tested Applications |
ELISA |
Host |
Mouse |
Recommended dilutions |
ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Purified recombinant fragment of DDR1 (aa602-681) expressed in E. coli. |
Isotype |
IgG1 |
Form |
Liquid |
Purification |
Unpurified ascites. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
Q08345 (UniProt,
ExPASy)
|
Gene Symbol |
DDR1 |
GeneID |
780
|
OMIM |
600408
|
HGNC |
2730
|
Ensembl |
ENSG00000204580 |
Enzyme Commission Number |
EC 2.7.1.112
EC 2.7.10.1
|
Molecular Weight |
101 kDa |
Buffer |
Ascitic fluid containing 0.03% sodium azide. |
Concentration |
Not determined. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on Epithelial Discoidin Domain-Containing Receptor 1 (DDR1)