Epithelial Discoidin Domain-Containing Receptor 1 (DDR1) Antibody

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. The gene is located on chromosome 6p21.3 in proximity to several HLA class I genes.

Target	Epithelial Discoidin Domain-Containing Receptor 1 (DDR1)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human DDR1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q08345 (UniProt, ExPASy)
NCBI Accession	NP_001189450.1 NP_001189451.1 NP_001189452.1 NP_001945.3 NP_054699.2 NP_054700.2
Molecular Weight	Calculated MW: 101 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse DDR1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Epithelial Discoidin Domain-Containing Receptor 1 (DDR1)

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