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DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody
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Catalogue No: abx034309
Price:
US$326.25
(Size: 80 µl)
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DFFA is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.
Research Articles on DNA Fragmentation Factor Subunit Alpha (DFFA)
| Target | DNA Fragmentation Factor Subunit Alpha (DFFA) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 304-331 amino acids from the C-terminal region of human DFFA. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O00273 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5T6G5, Q5T6G6, Q96I97, Q9Y6C6 |
| UniProt Entry Name | DFFA_HUMAN |
| Gene Symbol | DFFA |
| KEGG | hsa:1676 |
| String | 9606.ENSP00000366237 |
| Molecular Weight | Calculated MW: 36.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |