Desert Hedgehog Protein (DHH) Antibody

This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.

Target	Desert Hedgehog Protein (DHH)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 195-223 amino acids from the Central region of human DHH.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O43323 (UniProt, ExPASy)
UniProt Secondary AC	Q15794
UniProt Entry Name	DHH_HUMAN
Gene Symbol	DHH
GeneID	50846
OMIM	233420
HGNC	2865
KEGG	hsa:50846
Ensembl	ENSG00000139549
String	9606.ENSP00000266991
Molecular Weight	Calculated MW: 43.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse DHH.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Desert Hedgehog Protein (DHH)

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