Dickkopf-Related Protein 3 (DKK3) Antibody

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Catalogue No: abx028489
Price: US$326.25
(Size: 80 µl)

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Dickkopf-Related Protein 3 (DKK3) Antibody
Dickkopf-Related Protein 3 (DKK3) Antibody Dickkopf-Related Protein 3 (DKK3) Antibody Dickkopf-Related Protein 3 (DKK3) Antibody

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Datasheet SDS
DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.

Target Dickkopf-Related Protein 3 (DKK3)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human DKK3.
Isotype IgG
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9UBP4 (UniProt, ExPASy)
UniProt Secondary AC A8K1I2, D3DQW1, Q9ULB7
UniProt Entry Name DKK3_HUMAN
NCBI Accession NP_001018067.1 NP_037385.2 NP_056965.3
String 9606.ENSP00000379762
Molecular Weight Calculated MW: 38.4 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Dickkopf-Related Protein 3 (DKK3)
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