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Cyclin-D-Binding Myb-Like Transcription Factor 1 (DMTF1) Antibody
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Catalogue No: abx029695
Price:
US$326.25
(Size: 80 µl)
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This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Research Articles on Cyclin-D-Binding Myb-Like Transcription Factor 1 (DMTF1)
| Target | Cyclin-D-Binding Myb-Like Transcription Factor 1 (DMTF1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 588-616 amino acids from the C-terminal region of human DMTF1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y222 (UniProt, ExPASy) |
| UniProt Entry Name | DMTF1_HUMAN |
| Gene Symbol | DMTF1 |
| String | 9606.ENSP00000378193 |
| Molecular Weight | Calculated MW: 84.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat DMTF1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |