DNA Methyltransferase 1 (Dnmt1) Antibody

DNA Methyltransferase 1 (Dnmt1) Antibody is a Rabbit Polyclonal antibody for the detection of DNMT1.

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).

Target	DNA Methyltransferase 1 (Dnmt1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	DNA(cytosine-5-)-methyltransferase 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P26358 (UniProt, ExPASy)
UniProt Secondary AC	A0AV63, B7ZLW6, Q9UHG5, Q9ULA2, Q9UMZ6
UniProt Entry Name	DNMT1_HUMAN
Gene Symbol	DNMT1
GeneID	1786
OMIM	126375
HGNC	2976
KEGG	hsa:1786
String	9606.ENSP00000352516
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on DNA Methyltransferase 1 (Dnmt1)

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