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DNA-Dependent Protein Kinase Catalytic Subunit Phospho-Thr2609 (PRKDC pT2609) Antibody
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Catalogue No: abx032004
Price:
US$326.25
(Size: 80 µl)
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Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Stem cell surface receptors and activate yeast MAPK pathway.
Research Articles on DNA-Dependent Protein Kinase Catalytic Subunit Phospho-Thr2609 (PRKDC pT2609)
| Target | DNA-Dependent Protein Kinase Catalytic Subunit Phospho-Thr2609 (PRKDC pT2609) |
| Clonality | Polyclonal |
| Target Modification | Thr2609 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T2609 of human DNA-PK. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P78527 (UniProt, ExPASy) |
| UniProt Entry Name | PRKDC_HUMAN |
| Gene Symbol | PRKDC |
| GeneID | 5591 |
| OMIM | 600899 |
| HGNC | 9413 |
| KEGG | hsa:5591 |
| Ensembl | ENSG00000253729 |
| String | 9606.ENSP00000313420 |
| Molecular Weight | Calculated MW: 469 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |