DNA Polymerase Gamma, Catalytic Subunit (POLG) Antibody

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Catalogue No: abx028437
Price: US$326.25
(Size: 80 µl)
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DNA Polymerase Gamma, Catalytic Subunit (POLG) Antibody
DNA Polymerase Gamma, Catalytic Subunit (POLG) Antibody DNA Polymerase Gamma, Catalytic Subunit (POLG) Antibody DNA Polymerase Gamma, Catalytic Subunit (POLG) Antibody

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Datasheet SDS
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Target DNA Polymerase Gamma, Catalytic Subunit (POLG)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications ELISA, WB, IHC, IF/ICC, FCM
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 1120-1148 amino acids from the C-terminal region of human POLG.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P54098 (UniProt, ExPASy)
UniProt Secondary AC Q8NFM2, Q92515
UniProt Entry Name DPOG1_HUMAN
KEGG hsa:5428
String 9606.ENSP00000268124
Molecular Weight Calculated MW: 140 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Rat POLG.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on DNA Polymerase Gamma, Catalytic Subunit (POLG)
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