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DNA Methyltransferase 3 Like (Dnmt3L) Antibody
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Catalogue No: abx025706
Price:
US$326.25
(Size: 80 µl)
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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.
Research Articles on DNA Methyltransferase 3 Like (Dnmt3L)
| Target | DNA Methyltransferase 3 Like (Dnmt3L) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 357-388 amino acids from the C-terminal region of human Dnmt3L. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UJW3 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PB42, Q9BUJ4 |
| UniProt Entry Name | DNM3L_HUMAN |
| NCBI Accession | NP_037501.2 NP_787063.1 |
| String | 9606.ENSP00000270172 |
| Molecular Weight | Calculated MW: 43.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |