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Docking Protein 1 (DOK1) Antibody
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Catalogue No: abx033622
Price:
US$326.25
(Size: 80 µl)
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DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Research Articles on Docking Protein 1 (DOK1)
| Target | Docking Protein 1 (DOK1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human DOK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q99704 (UniProt, ExPASy) |
| UniProt Secondary AC | O43204, Q53TY2, Q9UHG6 |
| UniProt Entry Name | DOK1_HUMAN |
| KEGG | hsa:1796 |
| String | 9606.ENSP00000233668 |
| Molecular Weight | Calculated MW: 52.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat and Cow DOK1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |