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Down Syndrome Critical Region Protein 1 (DSCR1) Antibody
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Catalogue No: abx025111
Price:
US$290.00
(Size: 80 µl)
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DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.
Research Articles on Down Syndrome Critical Region Protein 1 (DSCR1)
| Target | Down Syndrome Critical Region Protein 1 (DSCR1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human DSCR1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P53805 (UniProt, ExPASy) |
| UniProt Entry Name | RCAN1_HUMAN |
| NCBI Accession | NP_004405.3 NP_981962.1 NP_981963.1 |
| KEGG | hsa:1827 |
| String | 9606.ENSP00000370527 |
| Molecular Weight | Calculated MW: 28.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow, Hamster and Sheep RCAN1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |