Dynein Light Chain 1, Cytoplasmic (DYNLL1) Antibody

DYNLL1 Antibody is a Rabbit Polyclonal antibody against DYNLL1. Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Target	Dynein Light Chain 1, Cytoplasmic (DYNLL1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-89 of human DYNLL1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P63167 (UniProt, ExPASy)
UniProt Secondary AC	Q15701
UniProt Entry Name	DYL1_HUMAN
Gene Symbol	DYNLL1
GeneID	8655
NCBI Accession	NP_003737.1
KEGG	hsa:8655
String	9606.ENSP00000376297
Molecular Weight	Calculated MW: 10 kDa Observed MW: 13 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	0.544 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Dynein Light Chain 1, Cytoplasmic (DYNLL1)

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