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E2F Transcription Factor 1 (E2F1) Antibody
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Catalogue No: abx001684
Price:
US$203.00
(Size: 20 µl)
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E2F1 Antibody is a Rabbit Polyclonal antibody against E2F1. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Research Articles on E2F Transcription Factor 1 (E2F1)
| Target | E2F Transcription Factor 1 (E2F1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/20 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 200-301 of human E2F1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q01094 (UniProt, ExPASy) |
| UniProt Secondary AC | Q13143, Q92768 |
| UniProt Entry Name | E2F1_HUMAN |
| Gene Symbol | E2F1 |
| GeneID | 1869 |
| NCBI Accession | NP_005216.1 |
| KEGG | hsa:1869 |
| String | 9606.ENSP00000345571 |
| Molecular Weight | Calculated MW: 47 kDa Observed MW: 60 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |