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3-Beta Hydroxysteroid-Delta-8, Delta-7 Isomerase (EBP) Antibody
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Catalogue No: abx031142
Price:
US$326.25
(Size: 80 µl)
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The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
Research Articles on 3-Beta Hydroxysteroid-Delta-8, Delta-7 Isomerase (EBP)
| Target | 3-Beta Hydroxysteroid-Delta-8, Delta-7 Isomerase (EBP) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 201-230 amino acids from the C-terminal region of human EBP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q15125 (UniProt, ExPASy) |
| UniProt Secondary AC | Q6FGL3, Q6IBI9 |
| UniProt Entry Name | EBP_HUMAN |
| Gene Symbol | EBP |
| GeneID | 10682 |
| OMIM | 300205 |
| HGNC | 3133 |
| KEGG | hsa:10682 |
| Ensembl | ENSG00000147155 |
| String | 9606.ENSP00000417052 |
| Molecular Weight | Calculated MW: 26.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |