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EF-Hand Calcium Binding Domain 4B (EFCAB4B) Antibody
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Catalogue No: abx029908
Price:
US$326.25
(Size: 80 µl)
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Ca (2+) binding protein that plays a key role in store-operated Ca (2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca (2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca (2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Research Articles on EF-Hand Calcium Binding Domain 4B (EFCAB4B)
| Target | EF-Hand Calcium Binding Domain 4B (EFCAB4B) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9BSW2 (UniProt, ExPASy) |
| UniProt Secondary AC | B4E1X0, B9EK63 |
| UniProt Entry Name | EFC4B_HUMAN |
| Gene Symbol | CRACR2A |
| String | 9606.ENSP00000409382 |
| Molecular Weight | Calculated MW: 83.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |